J. Michael McIntosh, MD

Journal Article

1. honaj, Santiago U, Harvey PJ, Tekarli B, Gajewiak J, Craik DJ, Camacho CJ， McIntosh JM (2024). Design, Synthesis, 严重急性呼吸综合征-冠状病毒-2刺状蛋白新型肽衍生物的结构-活性关系. J Med Chem, 67(11), 9587-9598. (Read full article)
2. 罗安，何军，于军，吴勇，Harvey PJ, Kasheverov IE, Kudryavtsev DS， McIntosh JM， Tsetlin VI, Craik DJ, Zhangsun D, Luo S （2024）. αO-Conotoxin GeXIVA异构体的天冬氨酸诱变揭示了精氨酸残基对α9α10烟碱乙酰胆碱受体的抑制至关重要. Int J Biol Macromol, 271(Pt 1), 132472. (Read full article)
3. Williams BM, Steed ND, Woolley JT, Moedl AA, Nelson CA, Jones GC, Burris MD, Arias HR, Kim OH, Jang EY, Hone AJ, McIntosh JM， yorgasjt, Steffensen SC （2024）. Catharanthine通过抑制α6-尼古丁受体和多巴胺转运体调节中脑边缘多巴胺传递和尼古丁精神运动效应. ACS Chem Neurosci, 15(9), 1738-1754. (Read full article)
4. Neves JLB, Urcino C, Chase K, Dowell C, Hone AJ, Morgenstern D, Chua VM, Ramiro IBL, Imperial JS, Leavitt LS, Phan J, Fisher FA, Watkins M, Raghuraman S, Tun JO, Ueberheide BM, McIntosh JM， Vasconcelos V, Olivera BM, Gajewiak J （2024）. 用星座药理学方法鉴定一种来自圆锥圆锥的新型α-圆锥毒素. Mar Drugs, 22(3). (Read full article)
5. 王辉，李霞，乔宇，王敏，王伟， McIntosh JM，张孙东，罗胜（2024）. αO-Conotoxin GeXIVA[1,[2]慢性奥沙利铂诱导的神经病变小鼠模型神经性疼痛减轻和基因表达改变. Mar Drugs, 22(1). (Read full article)
6. George AA, John SJ, Lucero LM, Eaton JB, Jaiswal E, Christensen SB, Gajewiak J, Watkins M, Cao Y, Olivera BM, Im W, McIntosh JM, Whiteaker P (2023). α- concontoxin PnIC类似物通过一种新的变构机制选择性抑制α7β2- α7-仅α7亚型烟碱乙酰胆碱受体. FASEB J, 38(1), e23374. (Read full article)
7. Jimnez-Pompa A, Arribas RL， McIntosh JM, Albillos A (2023). 不同的酪氨酸和丝氨酸/苏氨酸磷酸化/去磷酸化途径调节小鼠海马神经元中α7和α3β4烟碱受体亚型的表达. 生物化学，生物物理学，公共科学, 684, 149115. (Read full article)
8. 吴鑫，洪英杰，黄艳华，Clark RJ， McIntosh JM，陈志强，陈志强（2023）. α-conotoxins针对特定烟碱乙酰胆碱受体亚型的计算设计. Chemistry, e202302909. (Read full article)
9. Tae HS, ortold MO, Tekarli BJ, Manetti D, Romanelli MN， McIntosh JM，亚当斯DJ，阿里亚斯HR （2023）. DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), 伊博甘因的一种新衍生物, 通过不同变构机制抑制α7和α9α10烟碱乙酰胆碱受体. ACS Chem Neurosci, 14(14), 2537-2547. (Read full article)
10. Wadsworth HA, Anderson EQ, Williams BM, Ronstrm JW, Moen JK, Lee AM， McIntosh JM，吴杰，yorgasjt, Steffensen SC （2023）. α - 6烟碱受体在酒精诱导的gaba能突触传递中的作用及其对伏隔核胆碱能中间神经元的可塑性. Mol Neurobiol, 60(6), 3113-3129. (Read full article)
11. 黄恩PN，克里斯滕森SB， McIntosh JM (2022). RgIA4预防急性奥沙利铂诱导的冷性异位性痛需要α9-含烟碱乙酰胆碱受体和CD3(+) t细胞. Cells, 11(22). (Read full article)
12. Hone AJ, McIntosh JM (2022). 生物碱配体使人α - 10烟碱乙酰胆碱受体发挥功能. Front Pharmacol, 13, 981760. (Read full article)
13. Richter K, Papke RL, Stokes C, Roy DC, Espinosa ES, Wolf PMK, Hecker A, Liese J, Singh VK, Padberg W, Schlter KD, Rohde M, McIntosh JM， Morley BJ, Horenstein NA, Grau V, Simard AR （2022）. 两种烟碱乙酰胆碱受体配体抗炎特性的比较, 磷酸胆碱和pcf3 -二epp. Front Cell Neurosci, 16, 779081. (Read full article)
14. Jimnez-Pompa A, Sanz-Lzaro S, Omodolor RE, Medina-Polo J, gonzalez - enguita C, Blzquez J， McIntosh JM, Albillos A (2021). α7和α3β4烟碱受体间的串扰阻止其脱敏. J Neurosci, 42(7), 1173-1183. (Read full article)
15. 艾丁格F，施密特C，科赫C， McIntosh JM，马克曼M， Sander M, Padberg W, Grau V （2021）. α - 1抗胰蛋白酶在大鼠静脉-动脉体外膜氧合模型中的应用. Sci Rep, 11(1), 15849. (Read full article)
16. Fisher F, Zhang Y, Vincent PFY, Gajewiak J, Gordon TJ, Glowatzki E, Fuchs PA， McIntosh JM (2021). Cy3-RgIA-5727标记和抑制耳蜗毛细胞含α9的nAChRs. Front Cell Neurosci, 15, 697560. (Read full article)
17. Paguigan ND, Tun JO, Leavitt LS, Lin Z, Chase K, Dowell C, Deering-Rice CE, Lim AL, Karthikeyan M, Hughen RW, Zhang J, Peterson RT, Reilly CA, Light AR, Raghuraman S, McIntosh JM， Olivera BM, Schmidt EW （2021）. 烟碱乙酰胆碱受体部分拮抗剂聚酰胺来自被囊类及其掠食性海蛞蝓. ACS Chem Neurosci, 12(14), 2693-2704. (Read full article)
18. Gajewiak J, Christensen SB, Dowell C, Hararah F, Fisher F, Huynh PN, Olivera BM， McIntosh JM (2021). 选择性青霉胺替代使开发一种有效的镇痛肽，通过非阿片类药物为基础的机制. J Med Chem, 64(13), 9271-9278. (Read full article)
19. 郑宁，Christensen SB, Dowell C, Purushottam L, Skalicky JJ， McIntosh JM, Chou DH (2021). 亚甲基硫缩醛结合α-RgIA类似物作为人α9α10烟碱乙酰胆碱受体有效稳定拮抗剂治疗神经性疼痛的发现. J Med Chem, 64(13), 9513-9524. (Read full article)
20. Sethuramanujam S, Matsumoto A, deRosenroll G, Murphy-Baum B, Grosman C， McIntosh JM， Jing M, Li Y, Berson D, Yonehara K, Awatramani GB （2021）. 中枢神经系统快速多方向胆碱能传递. Nat Commun, 12(1), 1374. (Read full article)
21. Richter K, Ogiemwonyi-Schaefer R, Wilker S, Chaveiro AI, Agn A, Hecker M, Reichert M, Amati AL, Schlter KD, Manzini I, Schmalzing G, McIntosh JM，帕德伯格W，格劳V， Hecker A （2020）. 淀粉样β肽（Aβ1-42）逆转单核细胞IL-1β释放的胆碱能控制. J Clin Med, 9(9). (Read full article)
22. 郑宁，Christensen SB, Blakely A, Dowell C, Purushottam L， McIntosh JM, Chou DH (2020). 构象约束α-RgIA类似物作为人α9α10烟碱乙酰胆碱受体稳定肽拮抗剂的研究. J Med Chem, 63(15), 8380-8387. (Read full article)
23. Yu Z, McIntosh JMSadeghi SG, Glowatzki E （2020）. 前庭II型毛细胞突触的传出突触传递. J Neurophysiol, 124(2), 360-374. (Read full article)
24. Bjrn-Yoshimoto WE, Ramiro IBL, Yandell M， McIntosh JM， Olivera BM, Ellgaard L, Safavi-Hemami H （2020）. 诅咒还是治愈：对concontoxin研究的众多好处和生物安全问题的回顾. Biomedicines, 8(8). (Read full article)
25. Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A， McIntosh JM (2020). 用新型康肽拮抗剂测定大鼠肾上腺染色质细胞α3β2β4烟碱乙酰胆碱受体的表达. J Neurochem, 154(2), 158-176. (Read full article)
26. Rybin MJ, brien H, Ramiro IBL, Azam L， McIntosh JM， Olivera BM, Safavi-Hemami H, Yoshikami D （2020）. αM-Conotoxin MIIIJ阻断蛙和鱼神经肌肉连接处的烟碱乙酰胆碱受体. Toxins (Basel), 12(3). (Read full article)
27. Donvito G, Muldoon PP, Jackson KJ, Ahmad U, Zaveri NT， McIntosh JM，陈旭，Lichtman AH, Damaj MI （2018）. 神经元烟碱乙酰胆碱受体介导∆9 -四氢大麻酚依赖：小鼠和人类研究. Addict Biol, 25(1), e12691. (Read full article)
28. Toma W, Ulker E, Alqasem M, AlSharari SD， McIntosh JM, Damaj MI (2020). 疼痛的胆碱能调节的行为和分子基础：聚焦于烟碱乙酰胆碱受体. 神经科学, 45, 153-166. (Read full article)
29. Huynh PN, Giuvelis D, Christensen S, Tucker KL， McIntosh JM (2019). RgIA4加速紫杉醇诱导的大鼠神经性疼痛的恢复. Mar Drugs, 18(1). (Read full article)
30. van Hout M, Valdes A, Christensen SB, Tran PT, Watkins M, Gajewiak J, Jensen AA, Olivera BM， McIntosh JM (2019). 圆锥脑室α-Conotoxin VnIB是α6β4*烟碱乙酰胆碱受体的有效选择性拮抗剂. Neuropharmacology, 157, 107691. (Read full article)
31. 彭超，闫勇，金文杰，Engle SE, Berry JN， McIntosh JM， Neve RL, Drenan RM （2018）. 研究烟碱乙酰胆碱受体在胆碱能传递中的基因编辑载体. Eur J Neurosci, 50(3), 2224-2238. (Read full article)
32. 李建军，李建军，李建军，李建军，李建军，李建军，李建军，李建军，等。 McIntosh JM (2019). PeIA-5466：一种含有非天然氨基酸的新型肽拮抗剂，可选择性靶向α3β2烟碱乙酰胆碱受体. J Med Chem, 62(13), 6262-6275. (Read full article)
33. A, Richter K, Zakrzewicz D, Siebers K, Damm J, Agn A, Hecker A， McIntosh JM， Chamulitrat W, Krasteva-Christ G, Manzini I, Tikkanen R, Padberg W, Janciauskiene S, Grau V （2019）. SLPI抑制atp介导的人单核细胞IL-1β成熟：一个老玩家的新功能. Front Immunol, 10, 664. (Read full article)
34. Grau V, Richter K, Hone AJ， McIntosh JM (2019). conop肽[V11L；V16D]ArIB和RgIA4：鉴定单核细胞新型烟碱乙酰胆碱受体的有力工具. Front Pharmacol, 9, 1499. (Read full article)
35. Arribas-Blzquez M, Olivos-Or LA, Barahona MV, Snchez de LA Muela M, Solar V, Jimnez E, Gualix J， McIntosh JM， Ferrer-Montiel A, Miras-Portugal MT, Artalejo AR （2019）. 大鼠神经性疼痛模型中肾上腺髓质染色质细胞中P2X3和P2X7受体及TRPV1通道的过表达. Int J Mol Sci, 20(1). (Read full article)
36. Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM， Clementi F, Bolchi C, Gotti C, Pallavicini M （2018）. α - 7- nachr杂化α - 7-烷基氧基二苯乙烯结构的有效抗胶质母细胞瘤剂, α9-nAChR拮抗剂和促氧化丝裂蛋白. J Med Chem, 61(23), 10531-10544. (Read full article)
37. Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak J, Christensen S, Harvey PJ, Craik DJ, McIntosh JM (2018). α- concontoxin抑制人和大鼠α6β4烟碱乙酰胆碱受体效价的分子决定因素. J Biol Chem, 293(46), 17838-17852. (Read full article)
38. Chen DJ, Gao FF, Ma XK, Shi GG, Huang YB, Su QX, Sudweeks S, Gao M, Dharshaun T, Eaton JB, Chang YC, Mcintosh JM, Lukas RJ, Whiteaker P, Steffensen SC, Wu J (2018). α6/α3β2β3-nAChRs和α4β2-nAChRs在人上皮SH-EP1细胞系异种表达的药理学和功能比较. Acta Pharmacol Sin, 39(10), 1571-1581. (Read full article)
39. Richter K, Koch C, Perniss A, Wolf PM, Schweda EKH, wichman S, Wilker S, Magel I, Sander M， McIntosh JM，帕德伯格W，格劳V （2018）. 磷酸胆碱修饰的流感嗜血杆菌低脂糖抑制atp诱导的肺上皮细胞释放IL-1β. Molecules, 23(8). (Read full article)
40. Richter K, Sagawe S, Hecker A, Kllmar M, Askevold I, Damm J, Heldmann S, Phlmann M, Ruhrmann S, Sander M, Schlter KD, Wilker S, Knig IR, Kummer W, Padberg W, Hone AJ, McIntosh JM， Zakrzewicz AT, Koch C, Grau V （2018）. c反应蛋白刺激烟碱乙酰胆碱受体控制atp介导的单核细胞炎性体活化. Front Immunol, 9, 1604. (Read full article)
41. Mucchietto V, Fasoli F, Pucci S, Moretti M, Benfante R, Maroli A, Di Lascio S, Bolchi C, Pallavicini M, Dowell C, McIntosh M, Clementi F, Gotti C (2017). 含α9-和α7受体介导尼古丁对A549腺癌细胞的促增殖作用. Br J Pharmacol, 175(11), 1957-1972. (Read full article)
42. 闫燕，彭超，Arvin MC，金晓涛，Kim VJ, Ramsey MD，王勇，Banala S, Wokosin DL， McIntosh JM， Lavis LD, Drenan RM （2017）. VTA谷氨酸神经元中烟碱胆碱能受体调节兴奋性传递. Cell Rep, 23(8), 2236-2244. (Read full article)
43. sibers K, Fink B, Zakrzewicz A, Agn A, Richter K, Konzok S, Hecker A, Zukunft S, Kllmar M, Klein J McIntosh JM, Timm T, Sewald K, Padberg W, Aggarwal N, Chamulitrat W, Santoso S, Xia W, Janciauskiene S, Grau V (2018). α -1抗胰蛋白酶通过CD36和烟碱乙酰胆碱受体抑制atp介导的白介素-1β释放. Front Immunol, 9, 877. (Read full article)
44. Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL, Olivera BM, McIntosh JM (2017). 抑制α9α10烟碱乙酰胆碱受体可预防化疗引起的神经性疼痛. 美国国家科学基金委, 114(10), E1825-E1832. (Read full article)
45. 庞翔，刘磊，Ngolab J，赵雪R， McIntosh JM， Gardner PD, Tapper AR （2016）. Habenula胆碱能神经元通过尼古丁乙酰胆碱受体调节尼古丁戒断期间的焦虑. Neuropharmacology, 107, 294-304. (Read full article)
46. Baladi MG, Nielsen SM, McIntosh JM， Hanson GR, Fleckenstein AE （2016）. 先前尼古丁自我给药减轻大鼠甲基苯丙胺的多巴胺能缺陷：尼古丁乙酰胆碱受体的作用. Behav Pharmacol, 27(5), 422-30. (Read full article)
47. 张d， McGregor M, Bordia T, Perez XA， McIntosh JM， Decker MW, Quik M （2015）. α7烟碱受体激动剂可减轻左旋多巴诱导的运动障碍伴严重黑质纹状体损伤. Mov Disord, 30(14), 1901-1911. (Read full article)
48. Grady SR, Meinerz NM, Cao J, Reynolds AM, Picciotto MR, Changeux JP， McIntosh JM，马克斯·MJ，柯林斯AC （2001）. 尼古丁激动剂刺激小鼠脚间核释放乙酰胆碱：一种由不同的nAChR介导的功能，而不是纹状体释放多巴胺. J Neurochem, 76(1), 258-68. (Read full article)

Review

1. 裴顺，王宁，梅忠，张孙东，Craik DJ， McIntosh JM, Zhu X, Luo S (2024). 针对电压门控钠离子通道的Conotoxins. [Review]. Pharmacol Rev, 76(5), 828-845. (Read full article)
2. Hone AJ, McIntosh JM (2023). 烟碱乙酰胆碱受体：新型配体治疗疼痛和炎症的治疗靶点. [Review]. Pharmacol Res, 190, 106715. (Read full article)
3. Margiotta F, Micheli L, Ciampi C, Ghelardini C， McIntosh JM迪·切萨雷·曼内利（2022）. 源自松果的松果毒素：来自海洋生物的新的治疗机会. [Review]. Mar Drugs, 20(12). (Read full article)

Other

1. Sethuramanujam S, Matsumoto A, deRosenroll G, Murphy-Baum B, Grosman C， McIntosh JM， Jing M, Li Y, Berson D, Yonehara K, Awatramani GB （2021）. 作者更正：中枢神经系统快速多方向胆碱能传递. Nat Commun (12(1), p. 2441). England. (Read full article)

Patent

1. (2018). 神经性疼痛的治疗方法.
2. Gloria P. Corpuz, Robert M. Jones, James E. Garrett, Lourdes J. 约瑟夫·克鲁兹，迈克尔·麦金托什，大卫·R. Hillyard, 玛伦·沃特金斯，Baldomero M. Olivera (2015). Alpha-Conotoxin肽.
3. Gloria P. Corpuz, Robert M. Jones, James E. Garrett, Lourdes J. 约瑟夫·克鲁兹，迈克尔·麦金托什，大卫·R. Hillyard, 玛伦·沃特金斯，Baldomero M. Olivera (2014). 毒素肽，药物组合物及其用途.
4. Gloria P. Corpuz, Robert M. Jones, James E. Garrett, Lourdes J. 约瑟夫·克鲁兹，迈克尔·麦金托什，大卫·R. Hillyard, 玛伦·沃特金斯，Baldomero M. Olivera (2014). Alpha-Conotoxin肽.
5. 约瑟夫·迈克尔·麦金托什（2014）. 毒素肽，药物组合物及其用途.
6. 玛伦·沃特金斯，Baldomero M. Olivera, David R. Hillyard, J. 迈克尔·麦金托什，罗伯特·M. Jones (2013). Alpha-conotoxin肽. U.S. Patent No. 8487075. Washington, D.C.:U.S. 专利商标局.
7. J. 迈克尔·麦金托什，Baldomero M. 迈克尔·埃里森，米歇尔·A·奥利维拉. VINCLER (2012). CONOTOXIN PEPTIDES. U.S. Patent No. 20120220539. Washington, D.C.:U.S. 专利商标局.
8. J. 迈克尔·麦金托什（2012）. α - concontoxin mii类似物. U.S. Patent No. 20120122803. Washington, D.C.:U.S. 专利商标局.
9. McIntosh JM (2012). Alpha-conotoxin肽. U.S. Patent No. US 8110549 B2. Washington, D.C.:U.S. 专利商标局.
10. McIntosh, JM (2012). Alpha-conotoxin Analogs. U.S. Patent No. US 8101,573 B2. Washington, D.C.:U.S. 专利商标局.
11. McIntosh, JM (2011). Alpha-conotoxin肽. U.S. Patent No. US 7902153 B. Washington, D.C.:U.S. 专利商标局.
12. McIntosh JM (2008). - concontoxin MII类似物. U.S. Patent No. U.S. Patent 7,387,997. Washington, D.C.:U.S. 专利商标局.
13. McIntosh JM (2008). Conotoxin peptides. U.S. Patent No. U.S. Patent 7,368,432. Washington, D.C.:U.S. 专利商标局.
14. Watkins M, Olivera BM, Hillyard DR, McIntosh JM, Jones RM （2007）. Alpha-conotoxin肽. U.S. Patent No. 美国专利号7279549. Washington, D.C.:U.S. 专利商标局.
15. Joseph Michael McIntosh, Baldomero M. 奥利维拉、迈克尔·埃里森、米歇尔·文勒（2007）. 疼痛的治疗方法及镇痛化合物的筛选.
16. Olivera BM, McIntosh JM, Yoshikami D, Cartier GE, Luo S （2005）. Uses of .alpha.-conotoxin peptide. U.S. Patent No. 6,958,323. Washington, D.C.:U.S. 专利商标局.
17. Olivera BM, Layer RT, McIntosh JM, Nielsen JS, Jones RM （2005）. .alpha.-conotoxin peptides. U.S. Patent No. 6,855,805. Washington, D.C.:U.S. 专利商标局.
18. Watkins M, Olivera BM, Hillyard DR, McIntosh JM, Jones RM （2004）. .alpha.-conotoxin peptides. U.S. Patent No. 6,797,808. Washington, D.C.:U.S. 专利商标局.
19. Walker CS, Shetty R, Jimenez EC, McIntosh JM, Olivera BM, Watkins M, Jones RM, Shen GS （2004）. I-superfamily个. U.S. Patent No. 6,767,895. Washington, D.C.:U.S. 专利商标局.
20. McIntosh JM, Olivera BM, Cruz LJ, Corpuz GP, Jones RM, Garrett JE （2004）. Conotoxin peptides. U.S. Patent No. 6,767,896. Washington, D.C.:U.S. 专利商标局.
21. McIntosh JM, et al （2004）. α -螺毒素肽（澳大利亚）. U.S. Patent No. 770,076. Washington, D.C.:U.S. 专利商标局.
22. Olivera BM, McIntosh JM, Garrett JE, Cruz LJ, Jones RM, Cartier GE, Wagstaff JD （2004）. Mu-conopeptides. U.S. Patent No. 6,727,226. Washington, D.C.:U.S. 专利商标局.
23. Olivera BM, Cartier GE, Watkins M, Hillyard DR, McIntosh JM, Layer RT, Jones RM （2004）. o超家族螺毒素肽. U.S. Patent No. 6,762,165. Washington, D.C.:U.S. 专利商标局.
24. McIntosh JM (2004). o超家族螺毒素肽. U.S. Patent No. U.S. Patent 6,762,165. Washington, D.C.:U.S. 专利商标局.
25. McCabe RT，周立明，Layer RT, Olivera BM, McIntosh JM （2002）. Use of conantokins. U.S. Patent No. 6,399,574. Washington, D.C.:U.S. 专利商标局.
26. Olivera BM, McIntosh JM, McCabe RT, Layer RT，周立民（2001）. 使用止痛剂治疗疼痛. U.S. Patent No. 6,277,825. Washington, D.C.:U.S. 专利商标局.
27. Olivera BM, Layer RT, Watkins M, Hillyard DR, McIntosh JM, Schoenfeld R, Jones RM （2001）. .alpha.-conotoxin peptides. U.S. Patent No. 6,268,473. Washington, D.C.:U.S. 专利商标局.
28. Olivera BM, McIntosh JM, Yoshikami D, Cartier GE, Luo S （2001）. Uses of .alpha.-conotoxin peptides. U.S. Patent No. 6,265,541. Washington, D.C.:U.S. 专利商标局.
29. McCabe RT，周立民，Layer RT, Olivera BM, McIntosh JM （2001）. Use of conantokins. U.S. Patent No. 6,172,041. Washington, D.C.:U.S. 专利商标局.
30. 沈建军，Olivera BM, McIntosh JM （1999）. Conotoxin peptides. U.S. Patent No. 5,990,295. Washington, D.C.:U.S. 专利商标局.
31. McIntosh JM, Kulak JM, Yoshikami D, Olivera BM （1999）. Use of .alpha.- concontoxin用于治疗由尼古丁刺激的多巴胺释放引起的疾病. U.S. Patent No. 5,929,034. Washington, D.C.:U.S. 专利商标局.
32. McIntosh JM, Kulak JM, Yoshikami D, Olivera BM （1999）. Use of .alpha.- concontoxin用于治疗由尼古丁刺激的多巴胺释放引起的疾病. U.S. Patent No. 5,922,679. Washington, D.C.:U.S. 专利商标局.
33. Cruz LJ, Olivera BM, McIntosh JM, Jimenez E, Craig AG, Rivier JA, Julius D, England L （1999）. Bromo-tryptophan conopeptides. U.S. Patent No. 5,889,147. Washington, D.C.:U.S. 专利商标局.
34. McIntosh JM, Cartier GE, Yoshikami D, Luo S, Olivera BM （1999）. con多肽AuIA， AuIB和AuIC. U.S. Patent No. 5,866,682. Washington, D.C.:U.S. 专利商标局.
35. McIntosh JM, Kulak JM, Yoshikami D, Olivera BM （1998）. Use of .alpha.- concontoxin MII用于治疗由尼古丁刺激多巴胺释放引起的疾病. U.S. Patent No. 5,780,433. Washington, D.C.:U.S. 专利商标局.
36. Shon K-J, Olivera BM, McIntosh JM, Hasson A, Spira ME （1998）. Conotoxin peptides. U.S. Patent No. 5,719,264. Washington, D.C.:U.S. 专利商标局.
37. Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AO （1997）. Conotoxin peptides. U.S. Patent No. 5,633,347. Washington, D.C.:U.S. 专利商标局.
38. Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD （1997）. Conotoxin peptides. U.S. Patent No. 5,595,972. Washington, D.C.:U.S. 专利商标局.
39. Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD （1996）. 鉴定a系concontoxin肽编码核酸的工艺和引物. U.S. Patent No. 5,589,340. Washington, D.C.:U.S. 专利商标局.
40. Olivera BM, Cruz LJ, Hillyard DR, McIntosh JM, Santos AD （1996）. Conotoxin Peptides. U.S. Patent No. 5,514,774. Washington, D.C.:U.S. 专利商标局.

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